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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1697559생성일: 2026년 10월 25일

4-(Trifluoromethyl)phenylhydrazine → (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

https://huagongshe.com/reaction/1697559

반응식

참여 물질

역할이름HCID투입량
반응물4-(Trifluoromethyl)phenylhydrazineHCID 136200—
반응물(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylateHCID 86646820—
생성물(2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl EsterHCID 67278056—

반응 단계

In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester was reacted with 4-(trifluoromethyl)phenylhydrazine (CAS Reg. No. 368-90-1) to give the title compound as colorless solid. MS (ESI): m/z=528.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08163793B2
출처 데이터셋uspto-grants-2012_04
ORD IDord-bd0de03885de4f6b897823da5b10d825
출처 메모uspto-grants-2012_04