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Lithium Hydroxide → (2S,4R)-1-[5-Methyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | (2S,4R)-1-[5-Methyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 86646834 | — |
| 生成物 | (2S,4R)-1-[5-Methyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid | HCID 86646835 | — |
反応手順
In analogy to the procedure described in example 253e, (2S,4R)-1-[5-methyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow solid. MS (ESI): m/z=486.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163793B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-face3865252c4948bdc4f4bf868132e2 |
| 出典メモ | uspto-grants-2012_04 |