HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-Naphthalen-1-yl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Ethyl 1-naphthylaminoacetate | HCID 18347840 | — |
| Reactant | 1-Ethenesulfonyl-2-trifluoromethyl-benzene | HCID 23466718 | — |
| Product | 1-Naphthalen-1-yl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester | HCID 66771185 | — |
Reaction Steps
In analogy to the procedure described in example 343d, (naphthalen-1-ylamino)-acetic acid ethyl ester (CAS Reg. No. 107456-67-7) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as brown oil. MS (ESI): m/z=478.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-211ac833779b4b8a9b8ec5be950a30d1 |
| Source note | uspto-grants-2012_04 |