HCID 66770347, compound → HCID 66770513, compound

HRID 1697625Notes

Reaction equation

HRID 1697625 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=S)[CH2:24][C:25](=O)[CH3:26])=[O:4].Cl.[CH3:30][C:31]1[CH:36]=[C:35]([NH:37][NH2:38])[CH:34]=[C:33]([CH3:39])[N:32]=1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:20])([F:21])[F:22])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23]1[N:37]([C:35]2[CH:34]=[C:33]([CH3:39])[N:32]=[C:31]([CH3:30])[CH:36]=2)[N:38]=[C:25]([CH3:26])[CH:24]=1)=[O:4]

Participants

3

Reactant 2

HCID 66770347HCID 66770347, compoundHCID 86646823(2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Product 1

HCID 66770513HCID 66770513, compound

Procedure

In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with (2,6-dimethyl-pyridin-4-yl)-hydrazine hydrochloride (CAS Reg. No. 1187853-32-2) to give the title compound as brown oil. MS (ESI): m/z=523.2 [M+H]

Sources & evidence

ORD record
ord-23f0eff1ec6e4120a1d7e32033c99705
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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