HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4-(2-Trifluoromethyl-benzenesulfonyl)-1-(3-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | (3-Trifluoromethyl-phenylamino)-acetic acid ethyl ester | HCID 247832 | — |
| Reactant | 1-Ethenesulfonyl-2-trifluoromethyl-benzene | HCID 23466718 | — |
| Product | 4-(2-Trifluoromethyl-benzenesulfonyl)-1-(3-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester | HCID 86646848 | — |
Reaction Steps
In analogy to the procedure described in example 343d, (3-trifluoromethyl-phenylamino)-acetic acid ethyl ester (CAS Reg. No. 2445-84-3) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as off-white solid. MS (ESI): m/z=496.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-8752015ec8dc4356ab22e9d454881b05 |
| Source note | uspto-grants-2012_04 |