HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-(2-tert-Butyl-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | (2-Tert-butyl-phenylamino)-acetic acid ethyl ester | HCID 517578 | — |
| Reactant | 1-Ethenesulfonyl-2-trifluoromethyl-benzene | HCID 23466718 | — |
| Product | 1-(2-tert-Butyl-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester | HCID 66771186 | — |
Reaction Steps
In analogy to the procedure described in example 343d, (2-tert-butyl-phenylamino)-acetic acid ethyl ester (CAS Reg. No. 959563-17-8) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as colorless oil. MS (ESI): m/z=484.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b98f462caafd4813ba09f099a943a16a |
| Source note | uspto-grants-2012_04 |