HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-cyclopropyl-3-oxopropanoate → (2S,4R)-1-(3-Cyclopropyl-3-oxo-propionyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-cyclopropyl-3-oxopropanoate | HCID 11126948 | — |
| Reactant | (2S,4R)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 66771131 | — |
| Product | (2S,4R)-1-(3-Cyclopropyl-3-oxo-propionyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 86646850 | — |
Reaction Steps
In analogy to the procedure described in example 192f, (2S,4R)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192e) was reacted with 3-cyclopropyl-3-oxo-propionic acid tert-butyl ester (CAS Reg. No. 134302-07-1) to give the title compound as brown oil. MS (ESI): m/z=448.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-1ee783ab8f9f4317a37e7c65a3052c1e |
| Source note | uspto-grants-2012_04 |