HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 4-[2-Ethoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-piperidine-1-carboxylic Acid Tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Tert-butyl 4-[(2-ethoxy-2-oxoethyl)amino]piperidine-1-carboxylate | HCID 15380724 | — |
| Reactant | 1-Ethenesulfonyl-2-trifluoromethyl-benzene | HCID 23466718 | — |
| Product | 4-[2-Ethoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-piperidine-1-carboxylic Acid Tert-butyl Ester | HCID 66770890 | — |
Reaction Steps
In analogy to the procedure described in example 343d, 4-(ethoxycarbonylmethyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (CAS Reg. No. 177276-49-2) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-48affeb1e4be461487b322a38cb23f31 |
| Source note | uspto-grants-2012_04 |