2-Chloro-5-trifluoromethyl-(1,3,4)thiadiazole → HCID 59543645, compound

Participants

Reaction Steps

In analogy to the procedure described in example 335a, (2S,4R)-4-[4-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-benzenesulfonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide (example 211a) was reacted with 2-chloro-5-trifluoromethyl-[1,3,4]thiadiazole (CAS Reg. No. 53645-98-0) in a shaking reactor at 55° C. for 12 h to give the title compound as yellow solid. MS (ESI): m/z=638.1 [M+H]+.

Provenance & Evidence