Formaldehyde → HCID 86646853, compound

HRID 1697648Notes

Reaction equation

HRID 1697648 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:17])([F:16])[F:15])[CH:8]=1)[CH3:2].[CH2:19]=O.[CH:21]([S:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32]([F:35])([F:34])[F:33])(=[O:25])=[O:24])=[CH2:22]>>[CH2:1]([O:3][C:4]([CH:5]1[CH2:19][CH:21]([S:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[C:32]([F:33])([F:35])[F:34])(=[O:24])=[O:25])[CH2:22][N:6]1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]([F:15])([F:17])[F:16])[CH:8]=1)=[O:18])[CH3:2]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 234667181-Ethenesulfonyl-2-trifluoromethyl-benzeneHCID 28586102HCID 28586102, compound

Product 1

HCID 86646853HCID 86646853, compound

Procedure

In analogy to the procedure described in example 343d, (3-trifluoromethoxy-phenylamino)-acetic acid ethyl ester (CAS Reg. No. 1021237-80-8) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as off-white solid. MS (ESI): m/z=512.3 [M+H]+.

Sources & evidence

ORD record
ord-ebffd8d1607f4a42bbc42a5e281ff786
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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