HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl acetoacetate → (2S,4R)-methyl 4-(2-chloro-4-fluorophenylsulfonyl)-1-(3-oxobutanoyl)pyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl acetoacetate | HCID 15538 | — |
| Reactant | (2S,4R)-4-(2-chloro-4-fluoro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 66770675 | — |
| Product | (2S,4R)-methyl 4-(2-chloro-4-fluorophenylsulfonyl)-1-(3-oxobutanoyl)pyrrolidine-2-carboxylate | HCID 86646855 | — |
Reaction Steps
In analogy to the procedure described in example 192f, (2S,4R)-4-(2-chloro-4-fluoro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was reacted with tert-butyl acetoacetate to give the title compound as yellow foam. MS (ESI): m/z=406.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-5187f464213a4f42ac2ab4d366890d5d |
| Source note | uspto-grants-2012_04 |