HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylhydrazine dihydrochloride → (2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| Reactant | (2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate | HCID 86646820 | — |
| Product | (2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66770380 | — |
Reaction Steps
In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 253c) was reacted with benzylhydrazine dihydrochloride (CAS Reg. No. 20570-96-1) to give the title compound as orange oil. MS (ESI): m/z=474.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a2ddb2a2f2c74ba0852bc00d590387ab |
| Source note | uspto-grants-2012_04 |