HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → (2S,4R)-1-[1-Methyl-5-(tetrahydro-pyran-4-yl)-1H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | (2S,4R)-1-[3-oxo-3-(tetrahydro-pyran-4-yl)-thiopropionyl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 86646857 | — |
| Product | (2S,4R)-1-[1-Methyl-5-(tetrahydro-pyran-4-yl)-1H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66772551 | — |
Reaction Steps
In analogy to the procedure described in example 192 h, (2S,4R)-1-[3-oxo-3-(tetrahydro-pyran-4-yl)-thiopropionyl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was reacted with methylhydrazine (CAS Reg. No. 60-34-4) to give the title compound as colorless foam. MS (ESI): m/z=502.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-26837cb48de14f438de075c186e7723b |
| Source note | uspto-grants-2012_04 |