HCID 59543644, compound → HCID 59543508, compound

Participants

Reaction Steps

Palladium on charcoal 10% (5 mg) was added to a solution of 4-{5-[(2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic acid benzyl ester (12 mg, 18 umol; example 406c) in ethanol (1 ml). The reaction mixture was put under an hydrogen atmosphere and stirred at ambient temperature for 12 h. After filtration over dicalite the filtrate was brought to dryness to give the title compound (4.4 mg, 8 umol; 46%) as white solid. MS (ESI): m/z=551 [M+H]+.

Provenance & Evidence