HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → (2S,4R)-4-Cyclopropylmethanesulfonyl-pyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (2S,4R)-4-cyclopropylmethanesulfonyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester | HCID 66771843 | — |
| Product | (2S,4R)-4-Cyclopropylmethanesulfonyl-pyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester | HCID 66772266 | — |
Reaction Steps
In analogy to the procedure described in example 253e, (2S,4R)-4-cyclopropylmethanesulfonyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester was saponified in the presence of lithium hydroxide to give the title compound as white solid. MS (ESI): m/z=333.6 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-fbc2d202e3a7403a832fd4542e1f2b4d |
| Source note | uspto-grants-2012_04 |