HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Phenylmethyl)hydrazine → (2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-methanesulfonyl-pyrrolidine-2-carboxylic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Phenylmethyl)hydrazine | HCID 11157 | — |
| Reactant | (2S,4R)-4-methanesulfonyl-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646866 | — |
| Product | (2S,4R)-1-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-methanesulfonyl-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66770830 | — |
Reaction Steps
In analogy to the procedure described in example 192 h, (2S,4R)-4-methanesulfonyl-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 448c) was reacted with benzylhydrazine (CAS Reg. No. 555-96-4) to give the title compound. MS (ESI): m/z=378.5 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-444a74b10e46482382344ee22c7fbbf2 |
| Source note | uspto-grants-2012_04 |