3,3-Difluoroazetidine hydrochloride → HCID 59543499, compound

HRID 1697743Notes

Reaction equation

HRID 1697743 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[S:9]([C@H:12]1[CH2:16][N:15]([C:17]2[N:21]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[N:20]=[C:19]([CH3:28])[CH:18]=2)[C@H:14]([C:29]([NH:31][C:32]2([C:35]#[N:36])[CH2:34][CH2:33]2)=[O:30])[CH2:13]1)(=[O:11])=[O:10].Cl.[F:38][C:39]1([F:43])[CH2:42][NH:41][CH2:40]1>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([N:41]2[CH2:42][C:39]([F:43])([F:38])[CH2:40]2)[CH:5]=[CH:4][C:3]=1[S:9]([C@H:12]1[CH2:16][N:15]([C:17]2[N:21]([CH:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[N:20]=[C:19]([CH3:28])[CH:18]=2)[C@H:14]([C:29]([NH:31][C:32]2([C:35]#[N:36])[CH2:34][CH2:33]2)=[O:30])[CH2:13]1)(=[O:10])=[O:11]

Participants

4

Reactant 2

HCID 27582473,3-Difluoroazetidine hydrochlorideHCID 59543671HCID 59543671, compound

Product 1

HCID 59543499HCID 59543499, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In analogy to the procedure described in example 389, (2S,4R)-4-(2-chloro-4-fluorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxamide was reacted with 3,3-difluoroazetidine hydrochloride (CAS Reg. No. 288315-03-7) in acetonitrile at 90° C. for 48 h to give the title compound as off-white foam. MS (ESI): m/z=609.2 [M+H]+.

Sources & evidence

ORD record
ord-6c30289a674a439f9e22b90f5d374780
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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