HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → (2S,4R)-4-(2-Chlorophenylsulfonyl)-1-(3-methyl-1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (2S,4R)-4-(2-Chlorophenylsulfonyl)-1-(3-methyl-1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66772245 | — |
| Product | (2S,4R)-4-(2-Chlorophenylsulfonyl)-1-(3-methyl-1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylic Acid | HCID 66771874 | — |
Reaction Steps
In analogy to the procedure described in example 253e, (2S,4R)-4-(2-chlorophenylsulfonyl)-1-(3-methyl-1-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as brown liquid which was used in the next step without further purification. MS (ESI): m/z=470.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a64375734fb8430db4877e24cf00323c |
| Source note | uspto-grants-2012_04 |