5-(Hydrazinylmethyl)-1-methyl-1H-imidazole → HCID 66772677, compound

HRID 1697767Notes

Reaction equation

HRID 1697767 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C@H:11]1[CH2:15][N:14]([C:16](=S)[CH2:17][C:18](=O)[CH3:19])[C@H:13]([C:22]([O:24][CH3:25])=[O:23])[CH2:12]1)(=[O:10])=[O:9].[NH:26]([CH2:28][C:29]1[N:33]([CH3:34])[CH:32]=[N:31][CH:30]=1)[NH2:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C@H:11]1[CH2:15][N:14]([C:16]2[N:26]([CH2:28][C:29]3[N:33]([CH3:34])[CH:32]=[N:31][CH:30]=3)[N:27]=[C:18]([CH3:19])[CH:17]=2)[C@H:13]([C:22]([O:24][CH3:25])=[O:23])[CH2:12]1)(=[O:9])=[O:10]

Participants

3

Reactant 2

HCID 459342715-(Hydrazinylmethyl)-1-methyl-1H-imidazoleHCID 86646820(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate

Product 1

HCID 66772677HCID 66772677, compound

Procedure

In analogy to the procedure described in example 192 h, (2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate (example 253c) was reacted with 5-(hydrazinylmethyl)-1-methyl-1H-imidazole (CAS Reg. No. 887592-51-0) to give the title compound as yellow oil. MS (ESI): m/z=478.1 [M+H]

Sources & evidence

ORD record
ord-da2d793a84374999a465657e0a8ddcff
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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