1-Tert-butylpiperazine → HCID 59543841, compound

HRID 1697774Notes

Reaction equation

HRID 1697774 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[S:9]([C@H:12]1[CH2:16][N:15]([C:17]2[N:21]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[N:20]=[C:19]([CH3:28])[CH:18]=2)[C@H:14]([C:29]([NH:31][C:32]2([C:35]#[N:36])[CH2:34][CH2:33]2)=[O:30])[CH2:13]1)(=[O:11])=[O:10].[C:37]([N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)([CH3:40])([CH3:39])[CH3:38]>>[C:35]([C:32]1([NH:31][C:29]([C@@H:14]2[CH2:13][C@@H:12]([S:9]([C:3]3[CH:4]=[CH:5][C:6]([N:44]4[CH2:45][CH2:46][N:41]([C:37]([CH3:40])([CH3:39])[CH3:38])[CH2:42][CH2:43]4)=[CH:7][C:2]=3[Cl:1])(=[O:11])=[O:10])[CH2:16][N:15]2[C:17]2[N:21]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[N:20]=[C:19]([CH3:28])[CH:18]=2)=[O:30])[CH2:34][CH2:33]1)#[N:36]

Participants

3

Reactant 2

HCID 35305721-Tert-butylpiperazineHCID 59543671HCID 59543671, compound

Product 1

HCID 59543841HCID 59543841, compound

Procedure

In analogy to the procedure described in example 389, (2S,4R)-4-(2-chloro-4-fluorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxamide (example 464d) was reacted with 1-tert-butylpiperazine (CAS Reg. No. 38216-72-7) to give the title compound as colorless oil. MS (ESI): m/z=658.4 [M+H]+.

Sources & evidence

ORD record
ord-28476d2f0d5a4998ab3ad0a6e08c33f5
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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