HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 59234649, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (6-Fluoropyridin-3-yl)boronic acid | HCID 2783397 | — |
| Reactant | HCID 59234646 | HCID 59234646 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59234649 | HCID 59234649 | 53% |
Reaction Steps
The title compound was prepared in 53% yield using a similar procedure as set out earlier in Prep8 starting from 3-bromo-1-(4-chlorobutyl)-2(1H)-pyridinone (Prep7) (400 mg, 1.51 mmol), (6-fluoro-3-pyridinyl)boronic acid (commercial Synchem OHG product list) (426 mg, 3.02 mmol), K2CO3 (627 mg, 4.54 mmol), triphenylphosphine (200 mg, 0.75 mmol) and palladium(II)acetate (68 mg, 0.30 mmol) dissolved in dioxane (5 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163927B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-09a783befc794c5981f38504b1317a45 |
| Source note | uspto-grants-2012_04 |