HCID 58128670, compound → HCID 58128618, compound

HRID 1697873Notes

Reaction equation

HRID 1697873 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13]>C(O)C.[Pd]>[NH2:9][C:5]1[C:6]([CH3:8])=[CH:7][C:2]([F:1])=[C:3]([C:12](=[O:14])[CH3:13])[CH:4]=1

Participants

4

Reactant 1

HCID 58128670HCID 58128670, compound

Product 1

HCID 58128618HCID 58128618, compoundYield 60.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(2-Fluoro-4-methyl-5-nitro-phenyl)-ethanone (3.17 g) in ethanol (10 ml) was hydrogenated over Pd/C (200 mg) under balloon pressure over night. The mixture was filtered and the filtrate was concentrated under reduced pressure to a grey solid that was recrystallized (EtOAc Hexane) to give 1.625 g of 1-(5-amino-2-fluoro-4-methyl-phenyl)-ethanone as an off-white powder.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure to a grey solid
  3. customthat was recrystallized (EtOAc Hexane)

Sources & evidence

ORD record
ord-b01dcf90cccf44cb8c998f4e44e41929
Source dataset
uspto-grants-2012_04
Patent number
US08163929B2

Reaction notes

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