Hydrochloric Acid → HCID 178515265, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-6-benzyl-4-hydroxy-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (8.721 g, 0.03403 mol) and water (510.7 mL, 28.35 mol) were mixed and the mixture was heated at 100° C. Conc. HCl was added slowly until the sample dissolved. The mixture was cooled at 90° C. then sodium nitrite (7.044 g, 0.1021 mol) in water (68.05 mL, 3.778 mol) was added dropwise. The reaction mixture was stirred at 90° C. for 1 hour then vacuum filtered hot to provide the product cv (3.187 g, 36%).

Provenance & Evidence