Ethanol → HCID 59239148, compound

Participants

Reaction Conditions

Reaction Steps

6-benzyl-4-morpholino-2-(4-nitrophenyl)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (cy) (0.112 g, 0.260 mmol), stannous chloride dihydrate (0.310 g, 1.36 mmol) and ethanol (2.00 mL) were combined and stirred at 80° C. for 1 hour. The mixture was diluted with H2O and 10% MeOH in dichloromethane, extracted 3 times with 10% MeOH in dichloromethane. The combined organic extract was dried over Magnesium sulfate and concentrated to give compound cz (0.083 g, 80%): LC-MS: m/z=+434 (M+H)+; 1H NMR (400 MHz, DMSO) δ 9.10 (s, 2H), 7.24 (d, J=8.6, 2H), 7.14 (s, 2H), 6.91 (d, J=8.6, 2H), 4.64 (d, J=27.1, 4H), 3.80-3.60 (m, 11H).

Provenance & Evidence