(2-Aminopyrimidin-5-yl)boronic acid → HCID 44816463, compound

HRID 1697896Notes

Reaction equation

HRID 1697896 reaction equation
Cl[C:2]1[N:3]=[C:4]([C:19]2[CH2:20][CH2:21][O:22][CH2:23][CH:24]=2)[C:5]2C[CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][C:6]=2[N:7]=1.[NH2:25][C:26]1[N:31]=[CH:30][C:29](B(O)O)=[CH:28][N:27]=1>>[NH2:25][C:26]1[N:31]=[CH:30][C:29]([C:2]2[N:3]=[C:4]([CH:19]3[CH:20]=[CH:21][O:22][CH2:23][CH2:24]3)[C:5]3[CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:16])[CH3:17])=[O:13])[CH2:8][C:6]=3[N:7]=2)=[CH:28][N:27]=1

Participants

3

Reactant 2

HCID 17750211(2-Aminopyrimidin-5-yl)boronic acidHCID 86640104HCID 86640104, compound

Product 1

HCID 44816463HCID 44816463, compound

Procedure

Compound de was synthesized according to general procedure described in step 2 of Example 1 by reacting tert-butyl 2-chloro-4-(3,6-dihydro-2H-pyran-4-yl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate with 2-aminopyrimidin-5-ylboronic acid. LC-MS: m/z=397 (M+H)+.

Workup

  1. customCompound de was synthesized

Sources & evidence

ORD record
ord-bc753de29a5040ccb762d7acbf4363cf
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

Loading…