Methyl chloroformate → HCID 59239136, compound

HRID 1697910Notes

Reaction equation

[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[C:16]3[CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].Cl[C:29]([O:31][CH3:32])=[O:30]>>[CH2:1]([NH:3][C:4](=[O:5])[NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[C:16]3[CH2:21][N:20]([C:29]([O:31][CH3:32])=[O:30])[CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)[CH3:2]

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 44816299HCID 44816299, compound

Product 1

HCID 59239136HCID 59239136, compound

Procedure

Compound ee was prepared according to the procedure described in Example 5 by reacting 1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea with methyl chloroformate. LC-MS: m/z=+427 (M+H)+.

Workup

customCompound ee was prepared

Sources & evidence

ORD record: ord-90c0bc6e19b649b9b6f1e1f9bf153e40
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163763B2

Reaction notes

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