2-Chloronicotinonitrile → HCID 59239554, compound

HRID 1697913Notes

Reaction equation

HRID 1697913 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[C:30]([C:32]1[C:33](Cl)=[N:34][CH:35]=[CH:36][CH:37]=1)#[N:31]>>[C:30]([C:32]1[C:33]([N:20]2[CH2:21][CH2:22][C:16]3[C:15]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]4[CH3:29])=[N:14][C:13]([C:10]4[CH:9]=[CH:8][C:7]([NH:6][C:4]([NH:3][CH2:1][CH3:2])=[O:5])=[CH:12][CH:11]=4)=[N:18][C:17]=3[CH2:19]2)=[N:34][CH:35]=[CH:36][CH:37]=1)#[N:31]

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 46913570Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-Methyl-4-Morpholinyl]pyrido[3,4-d]pyriMidin-2-yl]phenyl]-

Product 1

HCID 59239554HCID 59239554, compound

Procedure

Compound eh was prepared according to the procedure described in Example 2 by reacting (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea with 3-cyano-2-chloropyridine. LC-MS: m/z=+499 (M+H)−.

Workup

  1. customCompound eh was prepared

Sources & evidence

ORD record
ord-33dd8112632944f8b19c0cf92e23c8be
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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