5-Methyl-1,3,4-oxadiazole-2-carboxylic acid → HCID 59239411, compound

HRID 1697924Notes

Reaction equation

HRID 1697924 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[CH3:30][C:31]1[O:35][C:34]([C:36](O)=[O:37])=[N:33][N:32]=1>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][CH2:21][N:20]([C:36]([C:34]4[O:35][C:31]([CH3:30])=[N:32][N:33]=4)=[O:37])[CH2:19][C:17]=3[N:18]=2)=[CH:11][CH:12]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 198119465-Methyl-1,3,4-oxadiazole-2-carboxylic acidHCID 46913570HCID 46913570, compound

Product 1

HCID 59239411HCID 59239411, compound

Procedure

Compound fa was prepared according to the procedure described in Example 213 by reacting (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea with 5-methyl-1,3,4-oxadiazole-2-carboxylic acid. LC-MS: m/z=+507 (M+H)+.

Workup

  1. customCompound fa was prepared

Sources & evidence

ORD record
ord-95d33be71db34f2a84b2dcd8ca8f6b37
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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