HCID 59239257, compound → HCID 59239432, compound

Participants

Reaction Steps

and (R)-tert-butyl 8-allyl-2-(4-(3-ethylureido)phenyl)-4-((S)-3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (fc2): Compounds fc1 and fc2 were prepared according to the procedure described in Example 2 step 2 by reacting tert-butyl 8-allyl-2-chloro-4-((S)-3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate with (4-ethylureido)phenylboronic acid pinacol ester. The diastereoisomers were separated by chrial column chromatography. LC-MS: m/z=+537 (M+H)+.

Provenance & Evidence