2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 59239541, compound

HRID 1697928Notes

Reaction equation

HRID 1697928 reaction equation
C([CH:4]1[C:9]2[N:10]=[C:11](Cl)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]3[CH3:20])[C:8]=2[CH2:7][CH2:6][N:5]1[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])C=C.CC1(C)C(C)(C)OB([C:37]2[CH:38]=[N:39][C:40]([NH2:43])=[N:41][CH:42]=2)O1>>[NH2:43][C:40]1[N:41]=[CH:42][C:37]([C:11]2[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]3[CH3:20])[C:8]3[CH2:7][CH2:6][N:5]([C:22]([O:24][C:25]([CH3:27])([CH3:28])[CH3:26])=[O:23])[CH2:4][C:9]=3[N:10]=2)=[CH:38][N:39]=1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 86640105HCID 86640105, compound

Product 1

HCID 59239541HCID 59239541, compound

Procedure

Compound fh was prepared according to the procedure described in Example 2 step 2 by reacting tert-butyl 8-allyl-2-chloro-4-((S)-3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine. LC-MS: m/z=+428 (M+H)+.

Workup

  1. customCompound fh was prepared

Sources & evidence

ORD record
ord-76a16bf6e5a846ab9993a7c8e9d01d28
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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