5-Indolylboronic acid → HCID 59239347, compound

HRID 1697930Notes

Reaction equation

HRID 1697930 reaction equation
C([CH:4]1[C:9]2[N:10]=[C:11](Cl)[N:12]=[C:13]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]3[CH3:20])[C:8]=2[CH2:7][CH2:6][N:5]1[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])C=C.[NH:29]1[C:37]2[C:32](=[CH:33][C:34](B(O)O)=[CH:35][CH:36]=2)[CH:31]=[CH:30]1>>[NH:29]1[C:37]2[C:32](=[CH:33][C:34]([C:11]3[N:12]=[C:13]([N:14]4[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]4[CH3:20])[C:8]4[CH2:7][CH2:6][N:5]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH2:4][C:9]=4[N:10]=3)=[CH:35][CH:36]=2)[CH:31]=[CH:30]1

Participants

3

Reactant 2

HCID 27343615-Indolylboronic acidHCID 86640105HCID 86640105, compound

Product 1

HCID 59239347HCID 59239347, compound

Procedure

Compound fm was prepared according to the procedure described in Example 2 step 2 by reacting tert-butyl 8-allyl-2-chloro-4-((S)-3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate with 1H-indol-5-ylboronic acid. LC-MS: m/z=+450 (M+H)−.

Workup

  1. customCompound fm was prepared

Sources & evidence

ORD record
ord-1c7000a287554edab103597ff670708c
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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