1,1,1-Trifluoro-2-iodoethane → HCID 59239565, compound

HRID 1697935Notes

Reaction equation

HRID 1697935 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH2:29][CH3:30])[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].[F:31][C:32]([F:36])([F:35])[CH2:33]I>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH2:29][CH3:30])[C:16]3[CH2:22][CH2:21][N:20]([CH2:33][C:32]([F:36])([F:35])[F:31])[CH2:19][C:17]=3[N:18]=2)=[CH:11][CH:12]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 67178678HCID 67178678, compound

Product 1

HCID 59239565HCID 59239565, compound

Procedure

Compound ha was synthesized using the general procedure described in Example 5 but by reacting (S)-1-ethyl-3-(4-(4-(3-ethylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea with 1,1,1-trifluoro-2-iodoethane instead of benzyl chloroformate: LC-MS: m/z=+493 (M+H)−.

Workup

  1. customCompound ha was synthesized

Sources & evidence

ORD record
ord-a32186a5679340a392f774205278f42e
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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