2-Hydroxyisobutyric acid → HCID 59239081, compound

Participants

Reaction Steps

Compound hr was prepared generally following the procedures described in Examples 1, 27 and 30 and 147 except that (S)-1-(2-hydroxyethyl)-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenyl)urea was used instead of tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate and 3S-3-methylmorpholine was used instead of morpholine in step 1 of Example 1. Additionally, 2-hydroxyisobutyric acid was used instead of oxazole-5-carboxylic acid in Example 147: LC/MS-m/z+499 (M+H)+.

Provenance & Evidence