HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine → (S)-1-(3-methylisoxazol-5-yl)-3-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | 5-Amino-3-methylisoxazole | HCID 84590 | — |
| Reactant | (S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline | HCID 67176513 | — |
| Reactant | 4-(4-Morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline | HCID 67177223 | — |
| Product | (S)-1-(3-methylisoxazol-5-yl)-3-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea | HCID 59239433 | — |
Reaction Steps
The title compound lf was prepared by the general procedure of Example 30 substituting (S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline for 4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline and 5-amino-3-methylisoxazole for cyclopropylmethylamine. LC-MS: m/z=+528 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163763B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a4363b98779b41b693926b8c0ce2e42e |
| Source note | uspto-grants-2012_04 |