Methyl iodide → HCID 59239140, compound

Participants

Reaction Steps

Step 1—Synthesis of (S)-6-(benzyloxy)-N-(4-(7-methyl-4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)pyridin-2-amine (mt): (S)-6-(benzyloxy)-N-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)pyridin-2-amine (ms) (100 mg, 0.2 mmol) was dissolved in DMF (2 mL) and DIPEA (159 μL, 0.9 mmol)). To this solution was added MeI (14 μL, 0.2 mmol) at rt. The resulting solution was stirred at rt for 4 hrs. It was diluted with H2O, extracted with EtOAc (2×10 mL). The combined organics were washed with brine, dried over Magnesium sulfate, filtered, concentrated in vacuo to afford 100 mg (100%) of the title compound mt. LC-MS: m/z=+524 (M+H)+.

Provenance & Evidence