3-Furancarboxaldehyde, tetrahydro- → HCID 59239277, compound

HRID 1697950Notes

Reaction equation

HRID 1697950 reaction equation
[CH3:1][C:2]1([CH3:36])[O:6][CH2:5][C@H:4]([N:7]2[CH2:16][CH2:15][C:14]3[C:13]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][C@@H:18]4[CH3:23])=[N:12][C:11]([C:24]4[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][CH2:34][CH3:35])=[O:32])=[CH:26][CH:25]=4)=[N:10][C:9]=3[CH2:8]2)[CH2:3]1.O1CCC(C=O)C1>>[CH3:36][C:2]1([CH3:1])[O:6][CH2:5][C@@H:4]([N:7]2[CH2:16][CH2:15][C:14]3[C:13]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][C@@H:18]4[CH3:23])=[N:12][C:11]([C:24]4[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][CH2:34][CH3:35])=[O:32])=[CH:26][CH:25]=4)=[N:10][C:9]=3[CH2:8]2)[CH2:3]1

Participants

3

Reactant 2

HCID 1575683-Furancarboxaldehyde, tetrahydro-HCID 59239484HCID 59239484, compound

Product 1

HCID 59239277HCID 59239277, compound

Procedure

and 1-(4-(7-((R)-5,5-dimethyltetrahydrofuran-3-yl)-4-((S)-3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea (no2): Compounds no1 and no2 were prepared by the general procedure of Example 267, by substituting 5,5-dimethyldihydrofuran-3(2H)-one for tetrahydrofuran-3-carbaldehyde, then followed by chiral separation to afford products no1 and no2. LC-MS: m/z=+495 (M+H)+.

Workup

  1. customfollowed by chiral separation
  2. customto afford products

Sources & evidence

ORD record
ord-029de6f6a4734943a9593ad5c5edd19c
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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