Cyclopropanemethanamine → (S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	Cyclopropanemethanamine	HCID 75646	—
Reactant	5-Methyl-1,3,4-oxadiazol-2-amine	HCID 2060250	—
Reactant	4-(4-Morpholino-6-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline	HCID 67176305	—
Reactant	(S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline	HCID 67176513	—
Product	(S)-1-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea	HCID 44815263	—

Reaction Steps

The title compound “of” was prepared by the general procedure of Example 30 substituting (S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline for 4-(4-morpholino-6-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline and 5-methyl-1,3,4-oxadiazol-2-amine for cyclopropylmethylamine. LC-MS: m/z=+529 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08163763B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-3b69499960874cbbaec8d60612af7281
Source note	uspto-grants-2012_04