4-Chloro-6-methylpyrimidine → HCID 59239536, compound

Participants

Reaction Steps

The compound op was prepared following the general procedure in Example 2, substituting 1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea with (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)phenyl)urea and substituting 2-Chloropyrimidine with 4-Chloro-6-methylpyrimidine. The desired product op (36% yield) was obtained as white powder: 1H NMR (500 MHz, DMSO) δ 8.70 (s, 1H), 8.42 (s, 1H), 8.20 (d, J=8.8 Hz, 2H), 7.49 (d, J=8.8 Hz, 2H), 6.80 (s, 1H), 6.19 (t, J=5.5 Hz, 1H), 4.10-3.62 (m, 9H), 3.52 (dd, J=11.0, 3.6 Hz, 1H), 3.21-3.02 (m, 5H), 2.88 (m, 2H), 2.28 (s, 3H), 1.12 (d, J=6.4 Hz, 3H), 1.06 (t, J=7.2 Hz, 3H); LC-MS m/z=503 (M+H).

Provenance & Evidence