4-Chlorobenzoyl chloride → 1-(4-(7-(4-Chlorobenzoyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

HRID 1697955Notes

Reaction equation

HRID 1697955 reaction equation
Cl.[CH2:2]([NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[C:16]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:17]3[CH2:23][CH2:22][NH:21][CH2:20][C:18]=3[N:19]=2)=[CH:10][CH:9]=1)=[O:6])[CH3:3].[Cl:30][C:31]1[CH:39]=[CH:38][C:34]([C:35](Cl)=[O:36])=[CH:33][CH:32]=1>>[Cl:30][C:31]1[CH:39]=[CH:38][C:34]([C:35]([N:21]2[CH2:22][CH2:23][C:17]3[C:16]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)=[N:15][C:14]([C:11]4[CH:10]=[CH:9][C:8]([NH:7][C:5]([NH:4][CH2:2][CH3:3])=[O:6])=[CH:13][CH:12]=4)=[N:19][C:18]=3[CH2:20]2)=[O:36])=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 671770581-Ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt

Product 1

HCID 448155921-(4-(7-(4-Chlorobenzoyl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Procedure

The compound pa was prepared following the general procedure described in Example 5 by reacting 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt with 4-Chlorobenzoic acid chloride: LC-MS m/z=521 (M+H).

Workup

  1. customThe compound pa was prepared

Sources & evidence

ORD record
ord-c5b77568fda7464e9fda1acc394824d5
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

Loading…