Dimethylformamide → HCID 59239561, compound

Participants

Reaction Steps

To a solution of 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea (bf) (115 mg, 0.300 mmol) in N,N-Dimethylformamide (2.00 mL) and N,N-Diisopropylethylamine (0.104 mL, 0.600 mmol) was added 6-chloror-1-methylpyridin-2(1H)-one (129 mg, 0.90 mmol) at room temperature. The reaction was kept at 140° C. overnight, followed by RPHPLC purification. The desired product pv (6.4 mg, 4.4% yield) was obtained as white powder: 1H NMR (400 MHz, DMSO) δ 8.64 (s, 1H), 8.19 (d, J=8.8 Hz, 2H), 7.48 (d, J=8.8 Hz, 2H), 7.38 (m, 1H), 6.19-6.10 (m, 2H), 6.01 (d, J=6.6, 1H), 4.15 (s, 2H), 3.80-3.71 (m, 4H), 3.53 (m, 4H), 3.48 (s, 3H), 3.24-3.06 (m, 4H), 2.86 (s, 2H), 1.06 (t, J=7.2 Hz, 3H); LC-MS m/z=490 (M+H).

Provenance & Evidence