1-Bromo-3-methoxypropane → HCID 59239267, compound

HRID 1697963Notes

Reaction equation

HRID 1697963 reaction equation
Cl.[CH2:2]([NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[C:16]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][C@@H:25]3[CH3:30])[C:17]3[CH2:23][CH2:22][NH:21][CH2:20][C:18]=3[N:19]=2)=[CH:10][CH:9]=1)=[O:6])[CH3:3].Br[CH2:32][CH2:33][CH2:34][O:35][CH3:36]>>[CH2:2]([NH:4][C:5]([NH:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[N:15]=[C:16]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][C@@H:25]3[CH3:30])[C:17]3[CH2:23][CH2:22][N:21]([CH2:32][CH2:33][CH2:34][O:35][CH3:36])[CH2:20][C:18]=3[N:19]=2)=[CH:12][CH:13]=1)=[O:6])[CH3:3]

Participants

3

Reactant 2

HCID 5245511-Bromo-3-methoxypropaneHCID 66687899HCID 66687899, compound

Product 1

HCID 59239267HCID 59239267, compound

Procedure

The compound rx was prepared following the general procedure in Example 296, substituting 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt for (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt and substituting 1-bromo-2-methoxyethane for 1-bromo-3-methoxypropane: LC-MS m/z=469 (M+H).

Workup

  1. customThe compound rx was prepared

Sources & evidence

ORD record
ord-fd973114651546dfadd7c9542a2c29ca
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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