HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1-methylpyridin-2(1H)-one → (S)-1-ethyl-3-(4-(7-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1-methylpyridin-2(1H)-one | HCID 15429187 | — |
| Reactant | Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-Methyl-4-Morpholinyl]pyrido[3,4-d]pyriMidin-2-yl]phenyl]- | HCID 46913570 | — |
| Product | (S)-1-ethyl-3-(4-(7-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea | HCID 59239115 | — |
Reaction Steps
The compound was prepared following the general procedure in Example 308, substituting 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea for (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea and substituting 1-methylpyridin-2(1H)-one for 4-chloro-1-methylpyridin-2(1H)-one: LC-MS m/z=504 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163763B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-d1fd55cba95d4f1492c8ffaf94026d64 |
| Source note | uspto-grants-2012_04 |