2-Chloro-5-fluoropyrimidine → HCID 59239113, compound

HRID 1697966Notes

Reaction equation

[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][CH2:24]3)[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].Cl[C:32]1[N:37]=[CH:36][C:35]([F:38])=[CH:34][N:33]=1>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][CH2:24]3)[C:16]3[CH2:22][CH2:21][N:20]([C:32]4[N:37]=[CH:36][C:35]([F:38])=[CH:34][N:33]=4)[CH2:19][C:17]=3[N:18]=2)=[CH:11][CH:12]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 5834662-Chloro-5-fluoropyrimidine

HCID 59239593HCID 59239593, compound

Product 1

HCID 59239113HCID 59239113, compound

Procedure

The compound was prepared following the general procedure in Example 287, substituting (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)phenyl)urea for 1-ethyl-3-(4-(4-(4-methoxypiperidin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea and substituting 4-Chloro-6-methylpyrimidine for 2-Chloro-5-fluoropyrimidine: LC-MS m/z=507 (M+H).

Workup

customThe compound was prepared

Sources & evidence

ORD record: ord-4006e887fa3d4578a4cd5ca02cff2622
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163763B2

Reaction notes

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