1,4-Dioxane → HCID 59239310, compound

Participants

Reaction Steps

4-(7-Benzyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline (0.0500 g, 0.000124 mol) Palladium(II) acetate (0.0043 g, 0.000019 mol) Cesium Carbonate (0.0921 g, 0.000283 mol) 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.0255 g, 0.0000441 mol) and 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione (0.0321 g, 0.000200 mol) were combined, nitrogen purged three times, added dry 1,4-Dioxane (0.88 mL, 0.011 mol) The reaction was microwaved on 300 watts, 120° C. for 160 minutes on a CEM microwave. The reaction mixture was purified by HPLC. 1H NMR (400 MHz, DMSO) δ 10.36 (s, 1H), 8.53 (s, 1H), 8.27 (d, J=8.7, 2H), 7.42-7.34 (m, 4H), 7.28 (dd, J=15.1, 7.8, 3H), 5.01 (s, 1H), 3.72 (dd, J=9.7, 5.0, 6H), 3.55 (s, 2H), 3.50 (d, J=4.4, 4H), 3.08 (s, 3H), 2.68 (dd, J=18.0, 4.8, 4H). LC/MS-m/z+528.3 (M+H)+

Provenance & Evidence