Ethanolamine → HCID 59239518, compound

Participants

Reaction Conditions

Reaction Steps

(S)-2-(4-aminophenyl)-4-(3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carbaldehyde (0.100 g, 0.000283 mol) in dry 1,4-Dioxane (2.00 mL, 0.0256 mol) was added Triethylamine (0.0434 mL, 0.000311 mol) followed by 20% Phosgene in toluene (1:4, Phosgene:Toluene, 0.170 mL). The reaction mixture was heated at 50° C. for 1 hour. The reaction mixture was cooled to room temperature and then added ethanolamine (0.1020 mL, 0.001690 mol). The reaction mixture was stirred overnight. The reaction mixture was concentrated and purified by HPLC. LC/MS-m/z+441.2 (M+H)+

Provenance & Evidence