Ethanol → HCID 136079653, compound

Participants

Reaction Steps

Step 3—Synthesis of compound vb: (S)-1-methyl-N-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenylcarbamothioyl)hydrazinecarboxamide (0.113 g, 0.000211 mol) and Ethanol (3.7 mL, 0.063 mol) were combined and the reaction was microwaved on 300 watts, 150° C. for 30 minutes on a CEM microwave. The reaction mixture was chromatographed through silica gel (0-5% MeOH in dichloromethane) and purified by HPLC. 1H NMR (400 MHz, DMSO) δ 9.34 (s, 1H), 8.43 (d, J=4.7, 2H), 8.22 (d, J=8.8, 2H), 7.47 (d, J=8.8, 2H), 6.69 (t, J=4.7, 1H), 4.88 (d, J=18.7, 1H), 4.73 (d, J=18.7, 1H), 4.17-4.04 (m, 2H), 3.91-3.79 (m, 2H), 3.70 (dd, J=11.3, 2.6, 1H), 3.61 (dd, J=9.9, 6.5, 3H), 3.43 (d, J=11.3, 1H), 3.23 (s, 3H), 2.73 (s, 2H), 1.25 (d, J=6.6, 3H). LC/MS-m/z+501.2 (M+H)+

Provenance & Evidence