Dimethylformamide → HCID 59239537, compound

Participants

Reaction Steps

1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea (0.042 g, 0.11 mmol) in dry N,N-Dimethylformamide (1.00 mL, 12.9 mmol) was added N,N-Diisopropylethylamine (0.0574 mL, 0.330 mmol) followed by 2,2-Dimethylpropanoyl chloride (0.0204 mL, 0.166 mmol). The reaction mixture was stirred for 3 days. The reaction mixture was concentrated and purified by HPLC. 1H NMR (400 MHz, DMSO) δ 8.65 (s, 1H), 8.19 (d, J=8.8, 2H), 7.48 (d, J=8.8, 2H), 6.16 (t, J=5.5, 1H), 4.61 (s, 2H), 3.81-3.68 (m, 6H), 3.49 (d, J=4.5, 4H), 3.19-3.06 (m, 2H), 2.69 (d, J=12.7, 2H), 1.27 (s, 9H), 1.06 (t, J=7.2, 3H). LC/MS-m/z+467.3 (M+H)+

Provenance & Evidence