Dimethylformamide → HCID 59239591, compound

Participants

Reaction Steps

1-Ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea (0.0507 g, 0.132 mmol) and 2,5-dichloropyrazine (0.0320 g, 0.215 mmol) were combined then added dry N,N-Dimethylformamide (0.910 mL, 11.8 mmol) followed by N,N-Diisopropylethylamine (0.0456 mL, 0.262 mmol). The reaction was microwaved on 200 watts, 120° C. for 30 minutes on a CEM microwave. The reaction mixture was purified by HPLC. 1H NMR (500 MHz, DMSO) δ 8.67 (s, 1H), 8.30 (d, J=2.5, 1H), 8.21 (d, J=8.7, 2H), 8.02 (d, J=2.5, 1H), 7.49 (d, J=8.8, 2H), 6.17 (t, J=5.6, 1H), 4.57 (s, 2H), 3.79-3.65 (m, 6H), 3.50 (d, J=4.3, 4H), 3.12 (dt, J=14.1, 7.1, 2H), 2.86 (s, 2H), 1.06 (t, J=7.2, 3H). LC/MS-m/z+495.2 (M+H)+

Provenance & Evidence