Dichloromethane → HCID 59239592, compound

Participants

Reaction Steps

Step 2—Synthesis of compound wa: (S)-tert-butyl 2-(4-(3-ethylureido)phenyl)-8,8-dimethyl-4-(3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (0.0861 g, 0.000164 mol) in Methylene chloride (2.00 mL, 0.0312 mol) was added Trifluoroacetic Acid (0.38 mL, 0.0049 mol). The reaction mixture was stirred for 1 hour. The reaction mixture was concentrated, diluted with sat NaHCO3, extracted three times with 10% MeOH in dichloromethane, dried over Magnesium sulfate, filtered, concentrated, and purified by HPLC. 1H NMR (400 MHz, DMSO) δ 8.66 (s, 1H), 8.19 (d, J=8.8, 2H), 7.48 (d, J=8.8, 2H), 6.17 (t, J=5.5, 1H), 4.02 (d, J=6.9, 1H), 3.86 (d, J=11.1, 1H), 3.70 (dd, J=11.2, 2.5, 1H), 3.61 (t, J=11.0, 2H), 3.44 (dd, J=22.6, 9.4, 2H), 3.18-3.04 (m, 2H), 2.90-2.77 (m, 2H), 2.55 (t, J=5.1, 2H), 1.40 (d, J=6.9, 6H), 1.22 (d, J=6.6, 3H), 1.06 (t, J=7.2, 3H). LC/MS-m/z+425.2 (M+H)+.

Provenance & Evidence