Acetic Acid → HCID 59239328, compound

Participants

Reaction Conditions

Reaction Steps

Step 2—Synthesis of compound wf: (S)-1-(2-(4-(6-(benzyloxy)pyridin-2-ylamino)phenyl)-4-(3-methylmorpholino)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone (0.098 g, 0.00018 mol), Palladium on Carbon 10% (0.1:0.9, Palladium:carbon black, 0.103 g), dry Methanol (5.00 mL, 0.123 mol) and Acetic acid (0.300 mL, 0.00528 mol) were combined under nitrogen then purged with hydrogen, heated at 65° C., and stirred overnight. The reaction mixture was purged with nitrogen, added celite, filtered through celite, concentrated, and purified by HPLC. 1H NMR (400 MHz, DMSO) δ 10.23 (s, 1H), 9.13 (s, 1H), 8.21 (d, J=8.6, 2H), 7.78 (s, 2H), 7.42 (t, J=7.9, 1H), 6.32 (s, 1H), 5.99 (s, 1H), 4.71-4.43 (m, 2H), 4.10 (s, 1H), 3.88 (d, J=11.2, 1H), 3.82-3.56 (m, 5H), 3.44 (dd, J=26.9, 16.5, 2H), 2.75 (s, 1H), 2.62 (s, 1H), 2.13 (s, 3H), 1.26 (t, J=5.9, 3H). LC/MS-m/z+461.2 (M+H)+

Provenance & Evidence